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Anti-Human UBXN1 Polyclonal Antibody (HC343014)

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Aperçu
Numéro de catalogueHC343014
Description
Anti-Human UBXN1 Polyclonal Antibody (HC343014) is a rabbit polyclonal antibody detecting UBXN1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactivité des espècesHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human UBXN1 (Asp212-Ser297).
Cible UBX domain-containing protein 1, UBXN1, SAPK substrate protein 1, UBA/UBX 33.3 kDa protein, SAKS1
Purification Purified by antigen affinity column.
Numéro d'accès Q04323
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

UBX domain-containing protein 1 (UBXN1) is a ~33 kDa protein. Ubiquitin-binding protein that plays a role in the modulation of innate immune response. Blocks both the RIG-I-like receptors (RLR) and NF-kappa-B pathways. Following viral infection, UBXN1 is induced and recruited to the RLR component MAVS. In turn, interferes with MAVS oligomerization, and disrupts the MAVS/TRAF3/TRAF6 signalosome. This function probably serves as a brake to prevent excessive RLR signaling.

1. Wang, P. et al. (2013) Cell reports 3, 1057-70. PMID: 23545497
2. Wang, YB. et al. (2015) The Journal of biological chemistry 290, 10395-405. PMID: 25681446
3. Hu, Y. et al. (2017) PLoS pathogens 13, e1006187. PMID: 28152074
4. Wu-Baer, F. et al. (2010) Molecular and cellular biology 30, 2787-98. PMID: 20351172
Note For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
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Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-Human UBXN1 Polyclonal Antibody

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