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| カタログ番号 | HC343014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human UBXN1 Polyclonal Antibody (HC343014) is a rabbit polyclonal antibody detecting UBXN1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human UBXN1 (Asp212-Ser297). | ||||||||
| ターゲット | UBX domain-containing protein 1, UBXN1, SAPK substrate protein 1, UBA/UBX 33.3 kDa protein, SAKS1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q04323 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | UBX domain-containing protein 1 (UBXN1) is a ~33 kDa protein. Ubiquitin-binding protein that plays a role in the modulation of innate immune response. Blocks both the RIG-I-like receptors (RLR) and NF-kappa-B pathways. Following viral infection, UBXN1 is induced and recruited to the RLR component MAVS. In turn, interferes with MAVS oligomerization, and disrupts the MAVS/TRAF3/TRAF6 signalosome. This function probably serves as a brake to prevent excessive RLR signaling. 1. Wang, P. et al. (2013) Cell reports 3, 1057-70. PMID: 23545497 2. Wang, YB. et al. (2015) The Journal of biological chemistry 290, 10395-405. PMID: 25681446 3. Hu, Y. et al. (2017) PLoS pathogens 13, e1006187. PMID: 28152074 4. Wu-Baer, F. et al. (2010) Molecular and cellular biology 30, 2787-98. PMID: 20351172 | ||||||||
| 注意事項 | For research use only. |
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