Anti-Human UGT1A1 Polyclonal Antibody (HA604014)

Name: Anti-Human UGT1A1 Polyclonal Antibody
Brand: abinScience
SKU: HA604014
Price: 168 USD
Availability: InStock

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SDS

Aperçu

Numéro de catalogue

HA604014

Description

Anti-Human UGT1A1 Polyclonal Antibody (HA604014) is a rabbit polyclonal antibody detecting UDP-glucuronosyltransferase 1A1; UGT1A1; 2.4.1.17; Bilirubin-specific UDPGT isozyme 1; hUG-BR1; UDP-glucuronosyltransferase 1-1; UDPGT 1-1; UGT1*1; UGT1-01; UGT1.1; UDP-glucuronosyltransferase 1A isoform 1; UGT1A1; GNT1; UGT1 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant human UGT1A1 (Gly28-Arg450).

Cible

UDP-glucuronosyltransferase 1A1; UGT1A1; 2.4.1.17; Bilirubin-specific UDPGT isozyme 1; hUG-BR1; UDP-glucuronosyltransferase 1-1; UDPGT 1-1; UGT1*1; UGT1-01; UGT1.1; UDP-glucuronosyltransferase 1A isoform 1; UGT1A1; GNT1; UGT1

Niveau d'endotoxines

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Numéro d'accès

P22309

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

UDP-glucuronosyltransferase 1A1 (UGT1A1) is a ~59 kDa protein. UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol, estrone and estriol. Involved in the glucuronidation of bilirubin, a degradation product occurring in the normal catabolic pathway that breaks down heme in vertebrates. Involved in the glucuronidation of arachidonic acid (AA) and AA-derived eicosanoids including 15-HETE, 20-HETE, PGB1 and F2-isoprostane (8-iso-PGF2alpha).

1. Gagné, JF. et al. (2002) Molecular pharmacology 62, 608-17. PMID: 12181437

2. Lépine, J. et al. (2004) The Journal of clinical endocrinology and metabolism 89, 5222-32. PMID: 15472229

3. Udomuksorn, W. et al. (2007) Pharmacogenetics and genomics 17, 1017-29. PMID: 18004206

4. Girard, H. et al. (2007) Pharmacogenetics and genomics 17, 1077-89. PMID: 18004212

5. Itäaho, K. et al. (2008) Drug metabolism and disposition: the biological fate of chemicals 36, 2307-15. PMID: 18719240

6. Sneitz, N. et al. (2010) Human mutation 31, 52-9. PMID: 19830808

7. Sneitz, N. et al. (2013) Drug metabolism and disposition: the biological fate of chemicals 41, 582-91. PMID: 23288867

8. Little, JM. et al. (2004) Journal of lipid research 45, 1694-703. PMID: 15231852

9. Li, X. et al. (2011) Drug metabolism and pharmacokinetics 26, 341-50. PMID: 21422672

10. Milne, GL. et al. (2024) Redox biology 70, 103020. PMID: 38211441

Note

For research use only

Images

Reférences

Fiche technique

Anti-Human UGT1A1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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