

| Numéro de catalogue | HY404014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-Human UNG Polyclonal Antibody (HY404014) is a rabbit polyclonal antibody detecting UNG. Suitable for Human.
|
||||||||
| Reactivité des espèces | Human | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human UNG (Ala45-Leu313). | ||||||||
| Cible | DGU, EC:3.2.2.27, UDG, UNG, UNG1, UNG15, Uracil-DNA glycosylase | ||||||||
| Niveau d'endotoxines | Please contact with the lab for this information. | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | P13051 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
||||||||
| Informations d'utilisation du produit |
| ||||||||
| Contexte | Uracil-DNA glycosylase (UNG) is a ~34 kDa protein. Uracil-DNA glycosylase that hydrolyzes the N-glycosidic bond between uracil and deoxyribose in single- and double-stranded DNA (ssDNA and dsDNA) to release a free uracil residue and form an abasic (apurinic/apyrimidinic; AP) site. Excises uracil residues arising as a result of misincorporation of dUMP residues by DNA polymerase during replication or due to spontaneous or enzymatic deamination of cytosine. Mediates error-free base excision repair (BER) of uracil at replication forks. According to the model, it is recruited by PCNA to S-phase replication forks to remove misincorporated uracil at U:A base mispairs in nascent DNA strands. Via trimeric RPA it is recruited to ssDNA stretches ahead of the polymerase to allow detection and excision of deaminated cytosines prior to replication. 1. Imai, K. et al. (2003) Nature immunology 4, 1023-8. PMID: 12958596 2. Kavli, B. et al. (2005) The Journal of experimental medicine 201, 2011-21. PMID: 15967827 3. Akbari, M. et al. (2007) Neuroscience 145, 1201-12. PMID: 17101234 4. Torseth, K. et al. (2012) DNA repair 11, 559-69. PMID: 22521144 5. Mol, CD. et al. (1995) Cell 82, 701-8. PMID: 7671300 6. Slupphaug, G. et al. (1996) Nature 384, 87-92. PMID: 8900285 7. Nilsen, H. et al. (1997) Nucleic acids research 25, 750-5. PMID: 9016624 8. Bharati, S. et al. (1998) Nucleic acids research 26, 4953-9. PMID: 9776759 | ||||||||
| Note | For research use only |
Contactez-nous pour les devis personnalisés, les demandes en gros et tout autre problème.
Courrier : [email protected]
Accès rapide
Contactez-nous
+86-027-65523339
Bâtiment C, No. 666, Rue Shendunsi, Wuhan, 430206, Chine
中文
English
한국어
日本語
Español
Français
Русский