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| カタログ番号 | HY404014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human UNG Polyclonal Antibody (HY404014) is a rabbit polyclonal antibody detecting UNG. Suitable for Human.
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human UNG (Ala45-Leu313). | ||||||||
| ターゲット | DGU, EC:3.2.2.27, UDG, UNG, UNG1, UNG15, Uracil-DNA glycosylase | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P13051 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | Uracil-DNA glycosylase (UNG) is a ~34 kDa protein. Uracil-DNA glycosylase that hydrolyzes the N-glycosidic bond between uracil and deoxyribose in single- and double-stranded DNA (ssDNA and dsDNA) to release a free uracil residue and form an abasic (apurinic/apyrimidinic; AP) site. Excises uracil residues arising as a result of misincorporation of dUMP residues by DNA polymerase during replication or due to spontaneous or enzymatic deamination of cytosine. Mediates error-free base excision repair (BER) of uracil at replication forks. According to the model, it is recruited by PCNA to S-phase replication forks to remove misincorporated uracil at U:A base mispairs in nascent DNA strands. Via trimeric RPA it is recruited to ssDNA stretches ahead of the polymerase to allow detection and excision of deaminated cytosines prior to replication. 1. Imai, K. et al. (2003) Nature immunology 4, 1023-8. PMID: 12958596 2. Kavli, B. et al. (2005) The Journal of experimental medicine 201, 2011-21. PMID: 15967827 3. Akbari, M. et al. (2007) Neuroscience 145, 1201-12. PMID: 17101234 4. Torseth, K. et al. (2012) DNA repair 11, 559-69. PMID: 22521144 5. Mol, CD. et al. (1995) Cell 82, 701-8. PMID: 7671300 6. Slupphaug, G. et al. (1996) Nature 384, 87-92. PMID: 8900285 7. Nilsen, H. et al. (1997) Nucleic acids research 25, 750-5. PMID: 9016624 8. Bharati, S. et al. (1998) Nucleic acids research 26, 4953-9. PMID: 9776759 | ||||||||
| 注意事項 | For research use only |
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