

| カタログ番号 | HF660014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human USP1 Polyclonal Antibody (HF660014) is a rabbit polyclonal antibody detecting USP1 in ELISA, IHC, WB. Suitable for Human, Mouse, Bovine, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human USP1 (Arg486-Lys599). | ||||||||
| ターゲット | Ubiquitin thioesterase 1, Ubiquitin carboxyl-terminal hydrolase 1, Deubiquitinating enzyme 1, Ubiquitin-specific-processing protease 1, USP1, hUBP | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O94782 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Ubiquitin carboxyl-terminal hydrolase 1 (USP1) is a ~88 kDa protein. Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. 1. Nijman, SM. et al. (2005) Molecular cell 17, 331-9. PMID: 15694335 2. Huang, TT. et al. (2006) Nature cell biology 8, 339-47. PMID: 16531995 3. Lee, KY. et al. (2010) The Journal of biological chemistry 285, 10362-9. PMID: 20147293 4. Cohn, MA. et al. (2007) Molecular cell 28, 786-97. PMID: 18082604 5. Yin, J. et al. (2015) Structure (London, England : 1993) 23, 2043-54. PMID: 26388029 | ||||||||
| 注意事項 | For research use only. |
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