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| カタログ番号 | HC297014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human USP10 Polyclonal Antibody (HC297014) is a rabbit polyclonal antibody detecting USP10 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human USP10 (Thr600-Leu798). | ||||||||
| ターゲット | Ubiquitin thioesterase 10, USP10, Ubiquitin carboxyl-terminal hydrolase 10, Ubiquitin-specific-processing protease 10, Deubiquitinating enzyme 10, KIAA0190 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q14694 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Ubiquitin carboxyl-terminal hydrolase 10 (USP10) is a ~87 kDa protein. Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, RPS2/us5, RPS3/us3, RPS10/eS10, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. 1. Soncini, C. et al. (2001) Oncogene 20, 3869-79. PMID: 11439350 2. Boulkroun, S. et al. (2008) American journal of physiology. Renal physiology 295, F889-900. PMID: 18632802 3. Meyer, C. et al. (2020) Molecular cell 77, 1193-1205.e5. PMID: 31981475 4. Yuan, J. et al. (2010) Cell 140, 384-96. PMID: 20096447 5. Liu, J. et al. (2011) Cell 147, 223-34. PMID: 21962518 6. Kedersha, N. et al. (2016) The Journal of cell biology 212, 845-60. PMID: 27022092 9. Sanders, DW. et al. (2020) Cell 181, 306-324.e28. PMID: 32302570 | ||||||||
| 注意事項 | For research use only. |
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