中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HW368014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human USP11 (Gly77-Asn292). | ||||||||
| ターゲット | Ubiquitin-specific-processing protease 11, Deubiquitinating enzyme 11, UHX1, USP11, Ubiquitin carboxyl-terminal hydrolase 11, Ubiquitin thioesterase 11 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P51784 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||||||
| 製品使用情報 |
| ||||||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Ubiquitin carboxyl-terminal hydrolase 11 (USP11) is a ~109 kDa protein. Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro). Plays a role in the regulation of pathways leading to NF-kappa-B activation. 1. Ideguchi, H. et al. (2002) The Biochemical journal 367, 87-95. PMID: 12084015 2. Schoenfeld, AR. et al. (2004) Molecular and cellular biology 24, 7444-55. PMID: 15314155 3. Yamaguchi, T. et al. (2007) The Journal of biological chemistry 282, 33943-8. PMID: 17897950 4. Sun, W. et al. (2010) Cellular signalling 22, 386-94. PMID: 19874889 5. Wiltshire, TD. et al. (2010) The Journal of biological chemistry 285, 14565-71. PMID: 20233726 6. Harper, S. et al. (2014) Biochemistry 53, 2966-78. PMID: 24724799 7. Wang, D. et al. (2018) Journal of molecular cell biology 10, 60-73. PMID: 28992046 | ||||||||
| 注意事項 | For research use only. |
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
