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Anti-Human USP20 Polyclonal Antibody (HP057014)

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Vista general
Número de catálogoHP057014
Reactividad de especiesHuman, Mouse
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human USP20 (Ser781-Val914).
Objetivo LSFR3A, Ubiquitin carboxyl-terminal hydrolase 20, KIAA1003, Ubiquitin-specific-processing protease 20, VHL-interacting deubiquitinating enzyme 2, Ubiquitin thioesterase 20, VDU2, hVDU2, Deubiquitinating enzyme 20, USP20
Purificación Purified by antigen affinity column.
Número de acceso Q9Y2K6
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Ubiquitin carboxyl-terminal hydrolase 20 (USP20) is a ~102 kDa protein. Deubiquitinating enzyme that plays a role in many cellular processes including autophagy, cellular antiviral response or membrane protein biogenesis. Attenuates TLR4-mediated NF-kappa-B signaling by cooperating with beta-arrestin-2/ARRB2 and inhibiting TRAF6 autoubiquitination. Promotes cellular antiviral responses by deconjugating 'Lys-33' and 'Lys-48'-linked ubiquitination of STING1 leading to its stabilization. Plays an essential role in autophagy induction by regulating the ULK1 stability through deubiquitination of ULK1. Acts as a positive regulator for NF-kappa-B activation by TNF through deubiquitinating 'Lys-48'-linked polyubiquitination of SQSTM1, leading to its increased stability.

1. Zhang, M. et al. (2016) Cell research 26, 1302-1319. PMID: 27801882
2. Kim, JH. et al. (2018) EMBO reports 19. PMID: 29487085
3. Jean-Charles, PY. et al. (2016) The Journal of biological chemistry 291, 7450-64. PMID: 26839314
4. Ha, J. et al. (2020) International journal of molecular sciences 21. PMID: 32354117
5. Berthouze, M. et al. (2009) The EMBO journal 28, 1684-96. PMID: 19424180
6. Li, Z. et al. (2005) EMBO reports 6, 373-8. PMID: 15776016
7. Feng, J. et al. (2022) Biochemical and biophysical research communications 593, 122-128. PMID: 35063767
Nota For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-Human USP20 Polyclonal Antibody

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