Anti-Human USP20 Polyclonal Antibody (HP057014)

Name: Anti-Human USP20 Polyclonal Antibody
Brand: abinScience
SKU: HP057014
Price: 168 USD
Availability: InStock

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Spécification :

50ug
100ug

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Aperçu
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Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HP057014

Reactivité des espèces

Human, Mouse

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human USP20 (Ser781-Val914).

Cible

LSFR3A, Ubiquitin carboxyl-terminal hydrolase 20, KIAA1003, Ubiquitin-specific-processing protease 20, VHL-interacting deubiquitinating enzyme 2, Ubiquitin thioesterase 20, VDU2, hVDU2, Deubiquitinating enzyme 20, USP20

Purification

Purified by antigen affinity column.

Numéro d'accès

Q9Y2K6

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Ubiquitin carboxyl-terminal hydrolase 20 (USP20) is a ~102 kDa protein. Deubiquitinating enzyme that plays a role in many cellular processes including autophagy, cellular antiviral response or membrane protein biogenesis. Attenuates TLR4-mediated NF-kappa-B signaling by cooperating with beta-arrestin-2/ARRB2 and inhibiting TRAF6 autoubiquitination. Promotes cellular antiviral responses by deconjugating 'Lys-33' and 'Lys-48'-linked ubiquitination of STING1 leading to its stabilization. Plays an essential role in autophagy induction by regulating the ULK1 stability through deubiquitination of ULK1. Acts as a positive regulator for NF-kappa-B activation by TNF through deubiquitinating 'Lys-48'-linked polyubiquitination of SQSTM1, leading to its increased stability.

1. Zhang, M. et al. (2016) Cell research 26, 1302-1319. PMID: 27801882

2. Kim, JH. et al. (2018) EMBO reports 19. PMID: 29487085

3. Jean-Charles, PY. et al. (2016) The Journal of biological chemistry 291, 7450-64. PMID: 26839314

4. Ha, J. et al. (2020) International journal of molecular sciences 21. PMID: 32354117

5. Berthouze, M. et al. (2009) The EMBO journal 28, 1684-96. PMID: 19424180

6. Li, Z. et al. (2005) EMBO reports 6, 373-8. PMID: 15776016

7. Feng, J. et al. (2022) Biochemical and biophysical research communications 593, 122-128. PMID: 35063767

Note

For research use only.

Images

Reférences

Fiche technique

Anti-Human USP20 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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