Anti-Human USP3 Polyclonal Antibody (HP965014)

Name: Anti-Human USP3 Polyclonal Antibody
Brand: abinScience
SKU: HP965014
Price: 168 USD
Availability: InStock

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Spécification :

50ug
100ug

Nombre :

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Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HP965014

Reactivité des espèces

Human, Mouse

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human USP3 (Gly316-Leu520).

Cible

Deubiquitinating enzyme 3, Ubiquitin thioesterase 3, USP3, Ubiquitin-specific-processing protease 3, Ubiquitin carboxyl-terminal hydrolase 3

Purification

Purified by antigen affinity column.

Numéro d'accès

Q9Y6I4

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Ubiquitin carboxyl-terminal hydrolase 3 (USP3) is a ~58 kDa protein. Deubiquitinase that plays a role in several cellular processes including transcriptional regulation, cell cycle progression or innate immunity. In response to DNA damage, deubiquitinates monoubiquitinated target proteins such as histone H2A and H2AX and thereby counteracts RNF168- and RNF8-mediated ubiquitination. In turn, participates in the recruitment of DNA damage repair factors to DNA break sites. Required for proper progression through S phase and subsequent mitotic entry. Acts as a positive regulator of TP53 by deubiquitinating and stabilizing it to promote normal cell proliferation and transformation.

1. Sharma, N. et al. (2014) Cell cycle (Georgetown, Tex.) 13, 106-14. PMID: 24196443

2. Nicassio, F. et al. (2007) Current biology : CB 17, 1972-7. PMID: 17980597

3. Fu, S. et al. (2017) Biochemical and biophysical research communications 492, 178-183. PMID: 28807825

4. Duan, T. et al. (2023) EMBO reports 24, e57828. PMID: 37971847

5. Cui, J. et al. (2014) Cell research 24, 400-16. PMID: 24366338

6. Zhuang, W. et al. (2022) Cellular & molecular immunology 19, 1141-1152. PMID: 36050480

Note

For research use only.

Images

Reférences

Fiche technique

Anti-Human USP3 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

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