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| カタログ番号 | HP965014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human USP3 (Gly316-Leu520). | ||||||||
| ターゲット | Deubiquitinating enzyme 3, Ubiquitin thioesterase 3, USP3, Ubiquitin-specific-processing protease 3, Ubiquitin carboxyl-terminal hydrolase 3 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9Y6I4 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Ubiquitin carboxyl-terminal hydrolase 3 (USP3) is a ~58 kDa protein. Deubiquitinase that plays a role in several cellular processes including transcriptional regulation, cell cycle progression or innate immunity. In response to DNA damage, deubiquitinates monoubiquitinated target proteins such as histone H2A and H2AX and thereby counteracts RNF168- and RNF8-mediated ubiquitination. In turn, participates in the recruitment of DNA damage repair factors to DNA break sites. Required for proper progression through S phase and subsequent mitotic entry. Acts as a positive regulator of TP53 by deubiquitinating and stabilizing it to promote normal cell proliferation and transformation. 1. Sharma, N. et al. (2014) Cell cycle (Georgetown, Tex.) 13, 106-14. PMID: 24196443 2. Nicassio, F. et al. (2007) Current biology : CB 17, 1972-7. PMID: 17980597 3. Fu, S. et al. (2017) Biochemical and biophysical research communications 492, 178-183. PMID: 28807825 4. Duan, T. et al. (2023) EMBO reports 24, e57828. PMID: 37971847 5. Cui, J. et al. (2014) Cell research 24, 400-16. PMID: 24366338 6. Zhuang, W. et al. (2022) Cellular & molecular immunology 19, 1141-1152. PMID: 36050480 | ||||||||
| 注意事項 | For research use only. |
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