Anti-Human USP3 Polyclonal Antibody (HP965014)

Name: Anti-Human USP3 Polyclonal Antibody
Brand: abinScience
SKU: HP965014
Price: 168 USD
Availability: InStock

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Спецификация:

50ug
100ug

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Обзор
Изображения
Ссылки
Даташит
SDS

Обзор

Каталожный номер

HP965014

Реактивность видов

Human, Mouse

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human USP3 (Gly316-Leu520).

Цель

Deubiquitinating enzyme 3, Ubiquitin thioesterase 3, USP3, Ubiquitin-specific-processing protease 3, Ubiquitin carboxyl-terminal hydrolase 3

Очистка

Purified by antigen affinity column.

Номер доступа

Q9Y6I4

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Ubiquitin carboxyl-terminal hydrolase 3 (USP3) is a ~58 kDa protein. Deubiquitinase that plays a role in several cellular processes including transcriptional regulation, cell cycle progression or innate immunity. In response to DNA damage, deubiquitinates monoubiquitinated target proteins such as histone H2A and H2AX and thereby counteracts RNF168- and RNF8-mediated ubiquitination. In turn, participates in the recruitment of DNA damage repair factors to DNA break sites. Required for proper progression through S phase and subsequent mitotic entry. Acts as a positive regulator of TP53 by deubiquitinating and stabilizing it to promote normal cell proliferation and transformation.

1. Sharma, N. et al. (2014) Cell cycle (Georgetown, Tex.) 13, 106-14. PMID: 24196443

2. Nicassio, F. et al. (2007) Current biology : CB 17, 1972-7. PMID: 17980597

3. Fu, S. et al. (2017) Biochemical and biophysical research communications 492, 178-183. PMID: 28807825

4. Duan, T. et al. (2023) EMBO reports 24, e57828. PMID: 37971847

5. Cui, J. et al. (2014) Cell research 24, 400-16. PMID: 24366338

6. Zhuang, W. et al. (2022) Cellular & molecular immunology 19, 1141-1152. PMID: 36050480

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-Human USP3 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

Наборы для анализа