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Anti-Human USP5 Polyclonal Antibody (HC178014)

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Vista general
Número de catálogoHC178014
Descripción
Anti-Human USP5 Polyclonal Antibody (HC178014) is a rabbit polyclonal antibody detecting USP5. Suitable for Mouse and Human.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Reactividad de especiesHuman, Mouse
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human USP5 (Lys163-Lys291).
Objetivo Deubiquitinating enzyme 5, EC:3.4.19.12, ISOT, Isopeptidase T, USP5, Ubiquitin carboxyl-terminal hydrolase 5, Ubiquitin thioesterase 5, Ubiquitin-specific-processing protease 5
Nivel de endotoxinas Please contact with the lab for this information.
Purificación Purified by antigen affinity column.
Número de acceso P45974
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Fondo

Ubiquitin carboxyl-terminal hydrolase 5 (USP5) is a ~95 kDa protein. Deubiquitinating enzyme that participates in a wide range of cellular processes by specifically cleaving isopeptide bonds between ubiquitin and substrate proteins or ubiquitin itself. Affects thereby important cellular signaling pathways such as NF-kappa-B, Wnt/beta-catenin, and cytokine production by regulating ubiquitin-dependent protein degradation. Participates in the activation of the Wnt signaling pathway by promoting FOXM1 deubiquitination and stabilization that induces the recruitment of beta-catenin to Wnt target gene promoter. Regulates the assembly and disassembly of heat-induced stress granules by mediating the hydrolysis of unanchored ubiquitin chains. Promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein.

1. Chen, Y. et al. (2016) The EMBO journal 35, 668-84. PMID: 26912724
2. Xie, X. et al. (2018) Journal of cell science 131. PMID: 29567855
3. Shi, S. et al. (2023) Hepatology communications 7. PMID: 37534934
4. Xiao, X. et al. (2023) Nature communications 14, 2859. PMID: 37208329
5. Pai, YL. et al. (2023) Cell death & disease 14, 540. PMID: 37607937
6. Qiao, Z. et al. (2025) PLoS pathogens 21, e1012843. PMID: 39761299
7. Mao, C. et al. (2024) The Journal of biological chemistry 300, 107592. PMID: 39032648
8. Shao, N. et al. (2025) Nature communications 16, 1313. PMID: 39900921
Nota For research use only
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Referencias
Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Human USP5 Polyclonal Antibody

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