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| カタログ番号 | HC178014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human USP5 Polyclonal Antibody (HC178014) is a rabbit polyclonal antibody detecting USP5. Suitable for Mouse and Human.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human USP5 (Lys163-Lys291). | ||||||||
| ターゲット | Deubiquitinating enzyme 5, EC:3.4.19.12, ISOT, Isopeptidase T, USP5, Ubiquitin carboxyl-terminal hydrolase 5, Ubiquitin thioesterase 5, Ubiquitin-specific-processing protease 5 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P45974 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | Ubiquitin carboxyl-terminal hydrolase 5 (USP5) is a ~95 kDa protein. Deubiquitinating enzyme that participates in a wide range of cellular processes by specifically cleaving isopeptide bonds between ubiquitin and substrate proteins or ubiquitin itself. Affects thereby important cellular signaling pathways such as NF-kappa-B, Wnt/beta-catenin, and cytokine production by regulating ubiquitin-dependent protein degradation. Participates in the activation of the Wnt signaling pathway by promoting FOXM1 deubiquitination and stabilization that induces the recruitment of beta-catenin to Wnt target gene promoter. Regulates the assembly and disassembly of heat-induced stress granules by mediating the hydrolysis of unanchored ubiquitin chains. Promotes lipopolysaccharide-induced apoptosis and inflammatory response by stabilizing the TXNIP protein. 1. Chen, Y. et al. (2016) The EMBO journal 35, 668-84. PMID: 26912724 2. Xie, X. et al. (2018) Journal of cell science 131. PMID: 29567855 3. Shi, S. et al. (2023) Hepatology communications 7. PMID: 37534934 4. Xiao, X. et al. (2023) Nature communications 14, 2859. PMID: 37208329 5. Pai, YL. et al. (2023) Cell death & disease 14, 540. PMID: 37607937 6. Qiao, Z. et al. (2025) PLoS pathogens 21, e1012843. PMID: 39761299 7. Mao, C. et al. (2024) The Journal of biological chemistry 300, 107592. PMID: 39032648 8. Shao, N. et al. (2025) Nature communications 16, 1313. PMID: 39900921 | ||||||||
| 注意事項 | For research use only |
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