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| カタログ番号 | HP280013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | SAA1602 | ||||
| ターゲット | VASHL, Vasohibin-2, VASH2, Vasohibin-like protein, Tubulinyl-Tyr carboxypeptidase 2 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | Q86V25 | ||||
| RRID | Anti-Human VASH2/Vasohibin-2 Antibody (SAA1602) (abinScience Cat# HP280013, RRID:AB_3727363) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Tubulinyl-Tyr carboxypeptidase 2 (VASH2/Vasohibin-2) is a ~40 kDa protein. Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Critical for spindle function and accurate chromosome segregation during mitosis since microtubule detyronisation regulates mitotic spindle length and postioning. Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis. Plays a role in axon formation. 1. Nieuwenhuis, J. et al. (2017) Science (New York, N.Y.) 358, 1453-1456. PMID: 29146869 2. Liao, S. et al. (2019) Cell research 29, 533-547. PMID: 31171830 3. Kimura, H. et al. (2009) Blood 113, 4810-8. PMID: 19204325 4. Wang, N. et al. (2019) Nature structural & molecular biology 26, 571-582. PMID: 31235911 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human VASH2/Vasohibin-2 Antibody (SAA1602)
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