Anti-Human VHL Monoclonal Antibody (1A522) (HW527025)

Name: Anti-Human VHL Monoclonal Antibody (1A522)
Brand: abinScience
SKU: HW527025
Price: 106 USD
Availability: InStock

Даташит Поделиться продуктом Копировать информацию

Цена(USD):

Спецификация:

20ug
50ug
100ug

Количество:

Свяжитесь с нами

Обзор
Изображения
Ссылки
Даташит
SDS

Обзор

Каталожный номер	HW527025
Описание	Anti-Human VHL Monoclonal Antibody (1A522) [1A522] (HW527025) is a mouse monoclonal antibody detecting VHL in ELISA, IHC, WB. Suitable for Human. Highlights ●Recombinant — Superior batch-to-batch reproducibility with defined sequences. ●Multi-Application — Validated across multiple applications.
Реактивность видов	Human
Применения	ELISA, IHC, WB
Хозяинский вид	Mouse
Клоональность	Monoclonal
Изотип	IgG
ID клона	1A522
Иммуноген	E. coli - derived recombinant human VHL (Glu70-Asp213).
Цель	von Hippel-Lindau disease tumor suppressor, Protein G7, pVHL, VHL
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	P40337
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон	von Hippel-Lindau disease tumor suppressor (VHL) is a ~24 kDa protein. Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2. Acts as a negative regulator of mTORC1 by promoting ubiquitination and degradation of RPTOR. 1. Tanimoto, K. et al. (2000) The EMBO journal 19, 4298-309. PMID: 10944113 2. Cheng, J. et al. (2007) Cell 131, 584-95. PMID: 17981124 3. Xie, L. et al. (2009) Science signaling 2, ra33. PMID: 19584355 4. Ganner, A. et al. (2021) Scientific reports 11, 14827. PMID: 34290272
Примечание	For research use only.