Anti-Human VHL Polyclonal Antibody (HW527014)

Name: Anti-Human VHL Polyclonal Antibody
Brand: abinScience
SKU: HW527014
Price: 168 USD
Availability: InStock

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Precio(USD):

Especificación:

50ug
100ug

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HW527014

Reactividad de especies

Human, Rat

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human VHL (Glu70-Asp213).

Objetivo

VHL, pVHL, Protein G7, von Hippel-Lindau disease tumor suppressor

Purificación

Purified by antigen affinity column.

Número de acceso

P40337

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

von Hippel-Lindau disease tumor suppressor (VHL) is a ~24 kDa protein. Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2. Acts as a negative regulator of mTORC1 by promoting ubiquitination and degradation of RPTOR.

1. Tanimoto, K. et al. (2000) The EMBO journal 19, 4298-309. PMID: 10944113

2. Cheng, J. et al. (2007) Cell 131, 584-95. PMID: 17981124

3. Xie, L. et al. (2009) Science signaling 2, ra33. PMID: 19584355

4. Ganner, A. et al. (2021) Scientific reports 11, 14827. PMID: 34290272

Nota

For research use only.

Imágenes

Referencias

Datasheet