Anti-Human VMAT2 Recombinant Antibody (JP0514) (HC560053)

Name: Anti-Human VMAT2 Recombinant Antibody (JP0514)
Brand: abinScience
SKU: HC560053
Price: 191 USD
Availability: InStock

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50ug
100ug
1mg

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Aperçu

Numéro de catalogue	HC560053
Reactivité des espèces	Human
Applications	FCM
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG1, kappa
ID de clone	JP0514
Cible	Synaptic vesicular amine transporter, Solute carrier family 18 member 2, Vesicular amine transporter 2, VAT2, Vesicular monoamine transporter 2, SLC18A2, SVMT, VMAT2
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	Q05940
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte	Synaptic vesicular amine transporter (VMAT2) is a ~55 kDa protein. Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports a variety of catecholamines such as dopamine, adrenaline and noradrenaline, histamine, and indolamines such as serotonin. Regulates the transvesicular monoaminergic gradient that determines the quantal size. Mediates somatodendritic dopamine release in hippocampal neurons, likely as part of a regulated secretory pathway that integrates retrograde synaptic signals. 1. Rilstone, JJ. et al. (2013) The New England journal of medicine 368, 543-50. PMID: 23363473 2. Pidathala, S. et al. (2023) Nature 623, 1086-1092. PMID: 37914936 3. Wu, D. et al. (2024) Nature 626, 427-434. PMID: 38081299 4. Dalton, MP. et al. (2024) eLife 12. PMID: 38517752 5. Erickson, JD. et al. (1996) Proceedings of the National Academy of Sciences of the United States of America 93, 5166-71. PMID: 8643547 6. Erickson, JD. et al. (1995) Journal of molecular neuroscience : MN 6, 277-87. PMID: 8860238
Note	For research use only

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Flow cytometry

HEK293T cells transiently transfected with human, mouse, rat, or pig VMAT1 or VMAT2 were stained with clone JP0514 at the indicated concentrations (0.01, 0.04, 0.16, 0.62, 2.5, and 10 µg/mL). The antibody specifically recognized human VMAT2, with no detectable binding to VMAT1 or to VMAT2 from other species.
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