Anti-Human VMAT2 Recombinant Antibody (JP1212) (HC560063)

Name: Anti-Human VMAT2 Recombinant Antibody (JP1212)
Brand: abinScience
SKU: HC560063
Price: 191 USD
Availability: InStock

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Referencias
Datasheet
SDS

Vista general

Número de catálogo	HC560063
Marca	abinScience
Reactividad de especies	Human, Porcine
Aplicaciones	FCM
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG1, kappa
ID de clon	JP1212
Objetivo	Synaptic vesicular amine transporter, Solute carrier family 18 member 2, Vesicular amine transporter 2, VAT2, Vesicular monoamine transporter 2, SLC18A2, SVMT, VMAT2
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>95% as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	Q05940, Q8BRU6, Q01827, Q01827, P54219, Q8R090, Q01818
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo	Synaptic vesicular amine transporter (VMAT2) is a ~55 kDa protein. Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports a variety of catecholamines such as dopamine, adrenaline and noradrenaline, histamine, and indolamines such as serotonin. Regulates the transvesicular monoaminergic gradient that determines the quantal size. Mediates somatodendritic dopamine release in hippocampal neurons, likely as part of a regulated secretory pathway that integrates retrograde synaptic signals. 1. Rilstone, JJ. et al. (2013) The New England journal of medicine 368, 543-50. PMID: 23363473 2. Pidathala, S. et al. (2023) Nature 623, 1086-1092. PMID: 37914936 3. Wu, D. et al. (2024) Nature 626, 427-434. PMID: 38081299 4. Dalton, MP. et al. (2024) eLife 12. PMID: 38517752 5. Erickson, JD. et al. (1996) Proceedings of the National Academy of Sciences of the United States of America 93, 5166-71. PMID: 8643547 6. Erickson, JD. et al. (1995) Journal of molecular neuroscience : MN 6, 277-87. PMID: 8860238
Nota	For research use only

Imágenes

Flow cytometry

HEK293T cells transiently transfected with human, mouse, rat, or pig VMAT1 or VMAT2 were stained with clone JP1212 at the indicated concentrations (0.01, 0.04, 0.16, 0.62, 2.5, and 10 µg/mL). The antibody recognized both VMAT1 and VMAT2 across all four species tested.
Binding affinity
Binding affinity

Referencias

Datasheet

Anti-Human VMAT2 Recombinant Antibody (JP1212).pdf

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Formula

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