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| カタログ番号 | HC560043 |
|---|---|
| ブランド | abinScience |
| 種反応性 | Human, Porcine |
| アプリケーション | FCM |
| 宿主種 | Human |
| クローン性 | Monoclonal |
| アイソタイプ | IgG1, kappa |
| クローンID | JP1217 |
| ターゲット | Synaptic vesicular amine transporter, Solute carrier family 18 member 2, Vesicular amine transporter 2, VAT2, Vesicular monoamine transporter 2, SLC18A2, SVMT, VMAT2 |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >95% as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | Q05940, M1PYC4 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 背景 | Synaptic vesicular amine transporter (VMAT2) is a ~55 kDa protein. Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports a variety of catecholamines such as dopamine, adrenaline and noradrenaline, histamine, and indolamines such as serotonin. Regulates the transvesicular monoaminergic gradient that determines the quantal size. Mediates somatodendritic dopamine release in hippocampal neurons, likely as part of a regulated secretory pathway that integrates retrograde synaptic signals. 1. Rilstone, JJ. et al. (2013) The New England journal of medicine 368, 543-50. PMID: 23363473 2. Pidathala, S. et al. (2023) Nature 623, 1086-1092. PMID: 37914936 3. Wu, D. et al. (2024) Nature 626, 427-434. PMID: 38081299 4. Dalton, MP. et al. (2024) eLife 12. PMID: 38517752 5. Erickson, JD. et al. (1996) Proceedings of the National Academy of Sciences of the United States of America 93, 5166-71. PMID: 8643547 6. Erickson, JD. et al. (1995) Journal of molecular neuroscience : MN 6, 277-87. PMID: 8860238 |
| 注意事項 | For research use only |
HEK293T cells transiently transfected with human, mouse, rat, or pig VMAT1 or VMAT2 were stained with clone JP1217 at the indicated concentrations (0.01, 0.04, 0.16, 0.62, 2.5, and 10 µg/mL). The antibody specifically recognized VMAT2 from human and pig, and did not detect VMAT1 or VMAT2 from mouse or rat.
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