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| カタログ番号 | HW488014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human VPS41 Polyclonal Antibody (HW488014) is a rabbit polyclonal antibody detecting VPS41 in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human VPS41 (Lys31-Asp361). | ||||||||
| ターゲット | Vacuolar protein sorting-associated protein 41 homolog, VPS41, S53 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P49754 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Vacuolar protein sorting-associated protein 41 homolog (VPS41) is a ~98 kDa protein. Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Acts as a component of the HOPS endosomal tethering complex. This complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo. 1. Solinger, JA. et al. (2013) The FEBS journal 280, 2743-57. PMID: 23351085 2. van der Welle, REN. et al. (2021) EMBO molecular medicine 13, e13258. PMID: 33851776 3. Pols, MS. et al. (2013) Traffic (Copenhagen, Denmark) 14, 219-32. PMID: 23167963 4. Lin, X. et al. (2014) Scientific reports 4, 7282. PMID: 25445562 5. Khatter, D. et al. (2015) Journal of cell science 128, 1746-61. PMID: 25908847 6. Radisky, DC. et al. (1997) Proceedings of the National Academy of Sciences of the United States of America 94, 5662-6. PMID: 9159129 7. Wartosch, L. et al. (2015) Traffic (Copenhagen, Denmark) 16, 727-42. PMID: 25783203 8. Zhang, S. et al. (2023) Nature communications 14, 6360. PMID: 37821429 9. Garg, S. et al. (2011) Immunity 35, 182-93. PMID: 21802320 | ||||||||
| 注意事項 | For research use only. |
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