Anti-Human VPS41 Polyclonal Antibody (HW488014)

Name: Anti-Human VPS41 Polyclonal Antibody
Brand: abinScience
SKU: HW488014
Price: 168 USD
Availability: InStock

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Каталожный номер

HW488014

Описание

Anti-Human VPS41 Polyclonal Antibody (HW488014) is a rabbit polyclonal antibody detecting VPS41 in ELISA, IHC, WB. Suitable for Human, Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Human, Mouse

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human VPS41 (Lys31-Asp361).

Цель

Vacuolar protein sorting-associated protein 41 homolog, VPS41, S53

Очистка

Purified by antigen affinity column.

Номер доступа

P49754

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Vacuolar protein sorting-associated protein 41 homolog (VPS41) is a ~98 kDa protein. Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Acts as a component of the HOPS endosomal tethering complex. This complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo.

1. Solinger, JA. et al. (2013) The FEBS journal 280, 2743-57. PMID: 23351085

2. van der Welle, REN. et al. (2021) EMBO molecular medicine 13, e13258. PMID: 33851776

3. Pols, MS. et al. (2013) Traffic (Copenhagen, Denmark) 14, 219-32. PMID: 23167963

4. Lin, X. et al. (2014) Scientific reports 4, 7282. PMID: 25445562

5. Khatter, D. et al. (2015) Journal of cell science 128, 1746-61. PMID: 25908847

6. Radisky, DC. et al. (1997) Proceedings of the National Academy of Sciences of the United States of America 94, 5662-6. PMID: 9159129

7. Wartosch, L. et al. (2015) Traffic (Copenhagen, Denmark) 16, 727-42. PMID: 25783203

8. Zhang, S. et al. (2023) Nature communications 14, 6360. PMID: 37821429

9. Garg, S. et al. (2011) Immunity 35, 182-93. PMID: 21802320

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-Human VPS41 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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Anti-Human VPS41 Polyclonal Antibody (HW488014)

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