Anti-Human WASL Polyclonal Antibody (HT262014)

Name: Anti-Human WASL Polyclonal Antibody
Brand: abinScience
SKU: HT262014
Price: 168 USD
Availability: InStock

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50ug
100ug

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Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HT262014

Reactivité des espèces

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human WASL (Leu21-Arg148).

Cible

N-WASP, WASL, Neural Wiskott-Aldrich syndrome protein

Purification

Purified by antigen affinity column.

Numéro d'accès

O00401

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Actin nucleation-promoting factor WASL is a ~54 kDa protein. Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization. Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression.

1. Wu, X. et al. (2006) Nature cell biology 8, 756-63. PMID: 16767080

2. Vingadassalom, D. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 6754-9. PMID: 19366662

3. Zhang, J. et al. (2009) The Journal of biological chemistry 284, 21659-69. PMID: 19487689

4. Gaucher, JF. et al. (2012) The Journal of biological chemistry 287, 34646-59. PMID: 22847007

5. Aitio, O. et al. (2012) Structure (London, England : 1993) 20, 1692-703. PMID: 22921828

6. Miki, H. et al. (1998) Nature 391, 93-6. PMID: 9422512

7. Rajabian, T. et al. (2009) Nature cell biology 11, 1212-8. PMID: 19767742

Note

For research use only.

Images

Reférences

Fiche technique

Anti-Human WASL Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

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