中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HT262014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human WASL (Leu21-Arg148). | ||||||||
| ターゲット | N-WASP, WASL, Neural Wiskott-Aldrich syndrome protein | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O00401 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||||||
| 製品使用情報 |
| ||||||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Actin nucleation-promoting factor WASL is a ~54 kDa protein. Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization. Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression. 1. Wu, X. et al. (2006) Nature cell biology 8, 756-63. PMID: 16767080 2. Vingadassalom, D. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 6754-9. PMID: 19366662 3. Zhang, J. et al. (2009) The Journal of biological chemistry 284, 21659-69. PMID: 19487689 4. Gaucher, JF. et al. (2012) The Journal of biological chemistry 287, 34646-59. PMID: 22847007 5. Aitio, O. et al. (2012) Structure (London, England : 1993) 20, 1692-703. PMID: 22921828 6. Miki, H. et al. (1998) Nature 391, 93-6. PMID: 9422512 7. Rajabian, T. et al. (2009) Nature cell biology 11, 1212-8. PMID: 19767742 | ||||||||
| 注意事項 | For research use only. |
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
