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| カタログ番号 | HP377024 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human WDR24 Polyclonal Antibody (HP377024) is a rabbit polyclonal antibody detecting WDR24. Suitable for Human and Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human WDR24 (Met21-Ala331). | ||||||||
| ターゲット | C16orf21, EC:2.3.2.27, GATOR2 complex protein WDR24, WD repeat-containing protein 24, WDR24 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q96S15 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | GATOR2 complex protein WDR24 is a ~88 kDa protein. Catalytic component of the GATOR2 complex, a multiprotein complex that acts as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex. 1. Bar-Peled, L. et al. (2013) Science (New York, N.Y.) 340, 1100-6. PMID: 23723238 2. Wolfson, RL. et al. (2016) Science (New York, N.Y.) 351, 43-8. PMID: 26449471 3. Saxton, RA. et al. (2016) Science (New York, N.Y.) 351, 53-8. PMID: 26586190 4. Saxton, RA. et al. (2016) Nature 536, 229-33. PMID: 27487210 5. Valenstein, ML. et al. (2022) Nature 607, 610-616. PMID: 35831510 6. Jiang, C. et al. (2023) Molecular cell 83, 74-89.e9. PMID: 36528027 7. Dai, X. et al. (2023) Nature metabolism 5, 265-276. PMID: 36732624 | ||||||||
| 注意事項 | For research use only |
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