

| Número de catálogo | HF771014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Descripción |
Anti-Human WFS1 Polyclonal Antibody (HF771014) is a rabbit polyclonal antibody detecting WFS1 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| Reactividad de especies | Human, Mouse | ||||||||
| Aplicaciones | ELISA, IHC, WB | ||||||||
| Especie huésped | Rabbit | ||||||||
| Clonalidad | Polyclonal | ||||||||
| Isotipo | IgG | ||||||||
| Inmunógeno | E. coli - derived recombinant Human WFS1 (Arg653-Ser869). | ||||||||
| Objetivo | WFS1, Wolframin | ||||||||
| Purificación | Purified by antigen affinity column. | ||||||||
| Número de acceso | O76024 | ||||||||
| Forma | Liquid | ||||||||
| Buffer de almacenamiento | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote. |
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| Información de uso del producto |
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| Estabilidad y almacenamiento | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Fondo | Wolframin (WFS1) is a ~100 kDa protein. Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store. Negatively regulates the ER stress response and positively regulates the stability of V-ATPase subunits ATP6V1A and ATP1B1 by preventing their degradation through an unknown proteasome-independent mechanism. 1. Takei, D. et al. (2006) FEBS letters 580, 5635-40. PMID: 16989814 2. Gharanei, S. et al. (2013) Human molecular genetics 22, 203-17. PMID: 23035048 | ||||||||
| Nota | For research use only. |
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