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| カタログ番号 | HD292014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human WIPI1 Polyclonal Antibody (HD292014) is a rabbit polyclonal antibody detecting WIPI1. Suitable for Human and Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human WIPI1 (Leu17-Leu360). | ||||||||
| ターゲット | Atg18 protein homolog, WD repeat domain phosphoinositide-interacting protein 1, WD40 repeat protein interacting with phosphoinositides of 49 kDa, WIPI 49 kDa, WIPI-1, WIPI1, WIPI49 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q5MNZ9 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | WD repeat domain phosphoinositide-interacting protein 1 (WIPI1) is a ~48 kDa protein. Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Plays an important role in starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions downstream of the ULK1 and PI3-kinases that produce phosphatidylinositol 3-phosphate (PtdIns3P) on membranes of the endoplasmic reticulum once activated. Binds phosphatidylinositol 3-phosphate (PtdIns3P), and maybe other phosphoinositides including PtdIns3,5P2 and PtdIns5P, and is recruited to phagophore assembly sites at the endoplasmic reticulum membranes. There, it assists WIPI2 in the recruitment of ATG12-ATG5-ATG16L1, a complex that directly controls the elongation of the nascent autophagosomal membrane. 1. Proikas-Cezanne, T. et al. (2004) Oncogene 23, 9314-25. PMID: 15602573 2. Grotemeier, A. et al. (2010) Cellular signalling 22, 914-25. PMID: 20114074 3. Geeraert, C. et al. (2010) The Journal of biological chemistry 285, 24184-94. PMID: 20484055 4. Itakura, E. et al. (2010) Autophagy 6, 764-76. PMID: 20639694 5. Gaugel, A. et al. (2012) Journal of molecular signaling 7, 16. PMID: 23088497 6. Bakula, D. et al. (2017) Nature communications 8, 15637. PMID: 28561066 7. Maeda, S. et al. (2019) eLife 8. PMID: 31271352 8. Kojima, W. et al. (2021) Autophagy 17, 2011-2036. PMID: 33499712 | ||||||||
| 注意事項 | For research use only |
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