

| Numéro de catalogue | HY026014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Reactivité des espèces | Human, Mouse | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human WNT1 (Gly32-Arg255). | ||||||||
| Cible | WNT1, Proto-oncogene Wnt-1, INT1, Proto-oncogene Int-1 homolog | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | P04628 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Proto-oncogene Wnt-1 (WNT1) is a ~40 kDa protein. Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Plays an essential role in the development of the embryonic brain and central nervous system (CNS). Has a role in osteoblast function, bone development and bone homeostasis. 1. Keupp, K. et al. (2013) American journal of human genetics 92, 565-74. PMID: 23499309 2. Laine, CM. et al. (2013) The New England journal of medicine 368, 1809-16. PMID: 23656646 3. Mihara, E. et al. (2016) eLife 5. PMID: 26902720 4. Won, JY. et al. (2017) European journal of medical genetics 60, 411-415. PMID: 28528193 | ||||||||
| Note | For research use only. |
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