

| Numéro de catalogue | HT367014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Reactivité des espèces | Human, Mouse | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human WNT7A (Asp57-Lys349). | ||||||||
| Cible | Protein Wnt-7a, WNT7A | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | O00755 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Protein Wnt-7a (WNT7A) is a ~39 kDa protein. Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway. Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation. Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal neural stem cell proliferation in the hippocampus dentate gyrus. 1. Woods, CG. et al. (2006) American journal of human genetics 79, 402-8. PMID: 16826533 2. Eubelen, M. et al. (2018) Science (New York, N.Y.) 361. PMID: 30026314 | ||||||||
| Note | For research use only. |
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