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Anti-Human WRAP53 Polyclonal Antibody (HA912014)

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Número de catálogoHA912014
Descripción
Anti-Human WRAP53 Polyclonal Antibody (HA912014) is a rabbit polyclonal antibody detecting WRAP53 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactividad de especiesHuman, Mouse, Rat
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human WRAP53 (Ser165-Tyr418).
Objetivo WD repeat-containing protein 79, TCAB1, WD40 repeat-containing protein antisense to TP53 gene, Telomerase Cajal body protein 1, WRAP53, WRAP53beta, WDR79
Purificación Purified by antigen affinity column.
Número de acceso Q9BUR4
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Telomerase Cajal body protein 1 (WRAP53) is a ~59 kDa protein. RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies. Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex. Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity.

1. Nguyen, THD. et al. (2018) Nature 557, 190-195. PMID: 29695869
2. Chen, L. et al. (2018) Cell 174, 218-230.e13. PMID: 29804836
3. Tycowski, KT. et al. (2009) Molecular cell 34, 47-57. PMID: 19285445
4. Egan, ED. et al. (2010) Molecular and cellular biology 30, 2775-86. PMID: 20351177
5. Venteicher, AS. et al. (2009) Science (New York, N.Y.) 323, 644-8. PMID: 19179534
6. Vogan, JM. et al. (2015) The Journal of biological chemistry 290, 21320-35. PMID: 26170453
Nota For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
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Volume
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g/mol
Formula
C₁ × V₁ = C₂ × V₂
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Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-Human WRAP53 Polyclonal Antibody

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