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| カタログ番号 | HA912014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human WRAP53 Polyclonal Antibody (HA912014) is a rabbit polyclonal antibody detecting WRAP53 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human WRAP53 (Ser165-Tyr418). | ||||||||
| ターゲット | WD repeat-containing protein 79, TCAB1, WD40 repeat-containing protein antisense to TP53 gene, Telomerase Cajal body protein 1, WRAP53, WRAP53beta, WDR79 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9BUR4 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Telomerase Cajal body protein 1 (WRAP53) is a ~59 kDa protein. RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies. Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex. Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity. 1. Nguyen, THD. et al. (2018) Nature 557, 190-195. PMID: 29695869 2. Chen, L. et al. (2018) Cell 174, 218-230.e13. PMID: 29804836 3. Tycowski, KT. et al. (2009) Molecular cell 34, 47-57. PMID: 19285445 4. Egan, ED. et al. (2010) Molecular and cellular biology 30, 2775-86. PMID: 20351177 5. Venteicher, AS. et al. (2009) Science (New York, N.Y.) 323, 644-8. PMID: 19179534 6. Vogan, JM. et al. (2015) The Journal of biological chemistry 290, 21320-35. PMID: 26170453 | ||||||||
| 注意事項 | For research use only. |
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