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Anti-Human WWC1 Polyclonal Antibody (HV200014)

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Número de catálogoHV200014
Descripción
Anti-Human WWC1 Polyclonal Antibody (HV200014) is a rabbit polyclonal antibody detecting WWC1. Suitable for Human and Mouse.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Reactividad de especiesHuman, Mouse
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human WWC1 (Arg661-Lys791).
Objetivo HBeAg-binding protein 3, KIAA0869, KIBRA, Kidney and brain protein, Protein KIBRA, WW domain-containing protein 1, WWC1
Nivel de endotoxinas Please contact with the lab for this information.
Purificación Purified by antigen affinity column.
Número de acceso Q8IX03
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Fondo

Protein KIBRA (WWC1) is a ~125 kDa protein. Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway. Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and function in the regulation of Hippo signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade.

1. Wennmann, DO. et al. (2014) Molecular biology and evolution 31, 1710-23. PMID: 24682284
2. Yu, J. et al. (2010) Developmental cell 18, 288-99. PMID: 20159598
3. Rayala, SK. et al. (2006) The Journal of biological chemistry 281, 19092-9. PMID: 16684779
4. Hilton, HN. et al. (2008) Biochimica et biophysica acta 1783, 383-93. PMID: 18190796
5. Duning, K. et al. (2008) Journal of the American Society of Nephrology : JASN 19, 1891-903. PMID: 18596123
6. Johannsen, S. et al. (2008) Neuroscience 155, 1165-73. PMID: 18672031
Nota For research use only
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Human WWC1 Polyclonal Antibody

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