中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HC509014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human XRCC4 (Met1-Lys115). | ||||||||
| ターゲット | DNA repair protein XRCC4, X-ray repair cross-complementing protein 4, XRCC4 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q13426 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||||||
| 製品使用情報 |
| ||||||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | DNA repair protein XRCC4 is a ~38 kDa protein. DNA non-homologous end joining (NHEJ) core factor, required for double-strand break repair and V(D)J recombination. Acts as a scaffold protein that regulates recruitment of other proteins to DNA double-strand breaks (DSBs). Associates with NHEJ1/XLF to form alternating helical filaments that bridge DNA and act like a bandage, holding together the broken DNA until it is repaired. The XRCC4-NHEJ1/XLF subcomplex binds to the DNA fragments of a DSB in a highly diffusive manner and robustly bridges two independent DNA molecules, holding the broken DNA fragments in close proximity to one other. The mobility of the bridges ensures that the ends remain accessible for further processing by other repair factors. 1. Nick McElhinny, SA. et al. (2000) Molecular and cellular biology 20, 2996-3003. PMID: 10757784 2. Chen, L. et al. (2000) The Journal of biological chemistry 275, 26196-205. PMID: 10854421 3. Lee, JW. et al. (2003) Cancer research 63, 22-4. PMID: 12517771 4. Foster, RE. et al. (2006) Biochemical and biophysical research communications 341, 175-83. PMID: 16412978 5. Mari, PO. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 18597-602. PMID: 17124166 6. Gu, J. et al. (2007) The EMBO journal 26, 1010-23. PMID: 17290226 7. Roy, S. et al. (2012) Nucleic acids research 40, 1684-94. PMID: 22228831 8. Wanotayan, R. et al. (2015) Biochemical and biophysical research communications 457, 526-31. PMID: 25597996 9. de Bruin, C. et al. (2015) The Journal of clinical endocrinology and metabolism 100, E789-98. PMID: 25742519 10. Fukuchi, M. et al. (2015) Biochemical and biophysical research communications 461, 687-94. PMID: 25934149 | ||||||||
| 注意事項 | For research use only. |
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
