Anti-Human YEATS4 Polyclonal Antibody (HF502014)

Name: Anti-Human YEATS4 Polyclonal Antibody
Brand: abinScience
SKU: HF502014
Price: 168 USD
Availability: InStock

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50ug
100ug

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Fiche technique
SDS

Aperçu

Numéro de catalogue

HF502014

Description

Anti-Human YEATS4 Polyclonal Antibody (HF502014) is a rabbit polyclonal antibody detecting YEATS4 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactivité des espèces

Human, Mouse

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human YEATS4 (Met1-Ile227).

Cible

Gas41, Glioma-amplified sequence 41, YEATS4, GAS41, NuBI1, NuBI-1, YEATS domain-containing protein 4, NuMA-binding protein 1

Purification

Purified by antigen affinity column.

Numéro d'accès

O95619

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

YEATS domain-containing protein 4 (YEATS4) is a ~26 kDa protein. Chromatin reader component of the NuA4 histone acetyltransferase (HAT) complex, a complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. Specifically recognizes and binds acylated histone H3, with a preference for histone H3 diacetylated at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac) or histone H3 diacetylated at 'Lys-14' and 'Lys-27' (H3K14ac and H3K27ac). Also able to recognize and bind crotonylated histone H3. May also recognize and bind histone H3 succinylated at 'Lys-122' (H3K122succ); additional evidences are however required to confirm this result in vivo. Plays a key role in histone variant H2AZ1/H2A.Z deposition into specific chromatin regions: recognizes and binds H3K14ac and H3K27ac on the promoters of actively transcribed genes and recruits NuA4-related complex to deposit H2AZ1/H2A.Z.

1. Cai, Y. et al. (2003) The Journal of biological chemistry 278, 42733-6. PMID: 12963728

2. Doyon, Y. et al. (2004) Molecular and cellular biology 24, 1884-96. PMID: 14966270

3. Hsu, CC. et al. (2018) Genes & development 32, 58-69. PMID: 29437725

4. Hsu, CC. et al. (2018) Cell discovery 4, 28. PMID: 29900004

5. Cho, HJ. et al. (2018) ACS chemical biology 13, 2739-2746. PMID: 30071723

6. Wang, Y. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, 2365-2370. PMID: 29463709

Note

For research use only.

Images

Reférences

Fiche technique

Anti-Human YEATS4 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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