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| カタログ番号 | HF502014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human YEATS4 Polyclonal Antibody (HF502014) is a rabbit polyclonal antibody detecting YEATS4 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human YEATS4 (Met1-Ile227). | ||||||||
| ターゲット | Gas41, Glioma-amplified sequence 41, YEATS4, GAS41, NuBI1, NuBI-1, YEATS domain-containing protein 4, NuMA-binding protein 1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O95619 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | YEATS domain-containing protein 4 (YEATS4) is a ~26 kDa protein. Chromatin reader component of the NuA4 histone acetyltransferase (HAT) complex, a complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. Specifically recognizes and binds acylated histone H3, with a preference for histone H3 diacetylated at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac) or histone H3 diacetylated at 'Lys-14' and 'Lys-27' (H3K14ac and H3K27ac). Also able to recognize and bind crotonylated histone H3. May also recognize and bind histone H3 succinylated at 'Lys-122' (H3K122succ); additional evidences are however required to confirm this result in vivo. Plays a key role in histone variant H2AZ1/H2A.Z deposition into specific chromatin regions: recognizes and binds H3K14ac and H3K27ac on the promoters of actively transcribed genes and recruits NuA4-related complex to deposit H2AZ1/H2A.Z. 1. Cai, Y. et al. (2003) The Journal of biological chemistry 278, 42733-6. PMID: 12963728 2. Doyon, Y. et al. (2004) Molecular and cellular biology 24, 1884-96. PMID: 14966270 3. Hsu, CC. et al. (2018) Genes & development 32, 58-69. PMID: 29437725 4. Hsu, CC. et al. (2018) Cell discovery 4, 28. PMID: 29900004 5. Cho, HJ. et al. (2018) ACS chemical biology 13, 2739-2746. PMID: 30071723 6. Wang, Y. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, 2365-2370. PMID: 29463709 | ||||||||
| 注意事項 | For research use only. |
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