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| カタログ番号 | HX994014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human YWHAG Polyclonal Antibody (HX994014) is a rabbit polyclonal antibody detecting YWHAG in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human YWHAG (Met1-Asn247). | ||||||||
| ターゲット | Protein kinase C inhibitor protein 1, 14-3-3 protein gamma, YWHAG, KCIP-1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P61981 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | 14-3-3 protein gamma (YWHAG) is a ~28 kDa protein. Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24. Participates in the positive regulation of NMDA glutamate receptor activity by promoting the L-glutamate secretion through interaction with BEST1. 1. Yoshida, K. et al. (2005) Nature cell biology 7, 278-85. PMID: 15696159 2. Jin, Y. et al. (2006) The EMBO journal 25, 1207-18. PMID: 16511572 3. Dai, X. et al. (2023) Nature metabolism 5, 265-276. PMID: 36732624 4. Oh, SJ. et al. (2017) Molecular brain 10, 51. PMID: 29121962 5. Rietscher, K. et al. (2018) Journal of cell science 131. PMID: 29678907 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-YWHAG polyclonal antibody at 1ug/mL on various samples.
Lane 1: NIH3T3 cell lysate
Lane 2: A431 cell lysate
Lane 3: K562 cell lysate
Lane 4: A549 cell lysate
Lane 5: 293T cell lysate
Lane 6: Jurkat cell lysate
Lane 7: U251 cell lysate
Lane 8: Mouse lung lysate
Lane 9: Rat brain lysate
Lane 10: Rat testis lysate
Lane11: Rat lung lysate
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