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| カタログ番号 | HB594014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human ZBED1 Polyclonal Antibody (HB594014) is a rabbit polyclonal antibody detecting E3 SUMO-protein ligase ZBED1; 2.3.2.-; DNA replication-related element-binding factor; Putative Ac-like transposable element; Zinc finger BED domain-containing protein 1; dREF homolog; ZBED1; ALTE; DREF; hDREF; KIAA0785; TRAMP in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human ZBED1 (Asp119-Cys290). | ||||||||
| ターゲット | E3 SUMO-protein ligase ZBED1; 2.3.2.-; DNA replication-related element-binding factor; Putative Ac-like transposable element; Zinc finger BED domain-containing protein 1; dREF homolog; ZBED1; ALTE; DREF; hDREF; KIAA0785; TRAMP | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O96006 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | E3 SUMO-protein ligase ZBED1 is a ~78 kDa protein. Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase which sumoylates CHD3/Mi2-alpha, causing its release from DNA. This results in suppression of CHD3/Mi2-alpha transcription repression, increased recruitment of RNA polymerase II to gene promoters and positive regulation of transcription including H1-5 and ribosomal proteins such as: RPS6, RPL10A, and RPL12. The resulting increased transcriptional activity drives cell proliferation. Binds to 5'-TGTCG[CT]GA[CT]A-3' consensus sequences in gene promoters of ribosomal proteins. 1. Yamashita, D. et al. (2016) The Journal of biological chemistry 291, 11619-34. PMID: 27068747 2. Ohshima, N. et al. (2003) The Journal of biological chemistry 278, 22928-38. PMID: 12663651 3. Yamashita, D. et al. (2007) The Journal of biological chemistry 282, 7563-75. PMID: 17209048 4. Yamashita, D. et al. (2007) Molecular and cellular biology 27, 2003-13. PMID: 17220279 | ||||||||
| 注意事項 | For research use only |
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