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| カタログ番号 | HY492014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human ZBTB48 Polyclonal Antibody (HY492014) is a rabbit polyclonal antibody detecting ZBTB48 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ZBTB48 (Val289-Leu628). | ||||||||
| ターゲット | Telomere zinc finger-associated protein, TZAP, Krueppel-related zinc finger protein 3, hKR3, Zinc finger and BTB domain-containing protein 48, Zinc finger protein 855, ZBTB48, HKR3, TZAP, ZNF855 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P10074 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Zinc finger and BTB domain-containing protein 48 (ZBTB48) is a ~77 kDa protein. Plays a critical role in transcriptional regulation and chromatin remodeling. Acts as a regulator of telomere length. Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres. Also acts as a transcription regulator that binds to promoter regions. 1. Li, JS. et al. (2017) Science (New York, N.Y.) 355, 638-641. PMID: 28082411 2. Jahn, A. et al. (2017) EMBO reports 18, 929-946. PMID: 28500257 3. Yoon, JH. et al. (2014) The Journal of biological chemistry 289, 4018-31. PMID: 24382891 4. Sugawara, M. et al. (1994) Molecular and cellular biology 14, 8438-50. PMID: 7969177 | ||||||||
| 注意事項 | For research use only. |
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