Anti-Human ZFP36 Polyclonal Antibody (HB820014)

Name: Anti-Human ZFP36 Polyclonal Antibody
Brand: abinScience
SKU: HB820014
Price: 168 USD
Availability: InStock

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Prix(USD) :

Spécification :

50ug
100ug

Nombre :

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Aperçu
Images
Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HB820014

Reactivité des espèces

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human ZFP36 (Thr106-Gly176).

Cible

Zinc finger protein 36, RNF162A, TIS11A, Growth factor-inducible nuclear protein NUP475, Zfp-36, ZFP36, G0/G1 switch regulatory protein 24, G0S24, Tristetraprolin, NUP475, mRNA decay activator protein ZFP36, TTP

Purification

Purified by antigen affinity column.

Numéro d'accès

P26651

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

mRNA decay activator protein ZFP36 is a ~34 kDa protein. Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation. Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs. Self regulates by destabilizing its own mRNA.

1. Lai, WS. et al. (1999) Molecular and cellular biology 19, 4311-23. PMID: 10330172

2. Lai, WS. et al. (2000) The Journal of biological chemistry 275, 17827-37. PMID: 10751406

3. Lai, WS. et al. (2001) The Journal of biological chemistry 276, 23144-54. PMID: 11279239

4. Brooks, SA. et al. (2002) Arthritis and rheumatism 46, 1362-70. PMID: 12115244

5. Lai, WS. et al. (2003) Molecular and cellular biology 23, 3798-812. PMID: 12748283

6. Brooks, SA. et al. (2004) Journal of immunology (Baltimore, Md. : 1950) 172, 7263-71. PMID: 15187101

7. Ogilvie, RL. et al. (2005) Journal of immunology (Baltimore, Md. : 1950) 174, 953-61. PMID: 15634918

8. Marderosian, M. et al. (2006) Oncogene 25, 6277-90. PMID: 16702957

9. Lai, WS. et al. (2006) Molecular and cellular biology 26, 9196-208. PMID: 17030620

10. Kedar, VP. et al. (2010) PloS one 5, e9588. PMID: 20221403

Note

For research use only.

Images

Reférences

Fiche technique

Anti-Human ZFP36 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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