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| カタログ番号 | HB820014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ZFP36 (Thr106-Gly176). | ||||||||
| ターゲット | Zinc finger protein 36, RNF162A, TIS11A, Growth factor-inducible nuclear protein NUP475, Zfp-36, ZFP36, G0/G1 switch regulatory protein 24, G0S24, Tristetraprolin, NUP475, mRNA decay activator protein ZFP36, TTP | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P26651 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | mRNA decay activator protein ZFP36 is a ~34 kDa protein. Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation. Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs. Self regulates by destabilizing its own mRNA. 1. Lai, WS. et al. (1999) Molecular and cellular biology 19, 4311-23. PMID: 10330172 2. Lai, WS. et al. (2000) The Journal of biological chemistry 275, 17827-37. PMID: 10751406 3. Lai, WS. et al. (2001) The Journal of biological chemistry 276, 23144-54. PMID: 11279239 4. Brooks, SA. et al. (2002) Arthritis and rheumatism 46, 1362-70. PMID: 12115244 5. Lai, WS. et al. (2003) Molecular and cellular biology 23, 3798-812. PMID: 12748283 6. Brooks, SA. et al. (2004) Journal of immunology (Baltimore, Md. : 1950) 172, 7263-71. PMID: 15187101 7. Ogilvie, RL. et al. (2005) Journal of immunology (Baltimore, Md. : 1950) 174, 953-61. PMID: 15634918 8. Marderosian, M. et al. (2006) Oncogene 25, 6277-90. PMID: 16702957 9. Lai, WS. et al. (2006) Molecular and cellular biology 26, 9196-208. PMID: 17030620 10. Kedar, VP. et al. (2010) PloS one 5, e9588. PMID: 20221403 | ||||||||
| 注意事項 | For research use only. |
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