中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HC370014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human ZFP36L1 Polyclonal Antibody (HC370014) is a rabbit polyclonal antibody detecting ZFP36L1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
|
||||||||
| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ZFP36L1 (Arg121-Arg195). | ||||||||
| ターゲット | ERF-1, ZFP36-like 1, TIS11B, BRF1, ZFP36L1, Butyrate response factor 1, Zinc finger protein 36, C3H1 type-like 1, ERF1, RNF162B, BERG36, TPA-induced sequence 11b, mRNA decay activator protein ZFP36L1, EGF-response factor 1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q07352 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||||||
| 製品使用情報 |
| ||||||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | mRNA decay activator protein ZFP36L1 is a ~36 kDa protein. Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Also induces the degradation of ARE-containing mRNAs even in absence of poly(A) tail. Binds to 3'-UTR ARE of numerous mRNAs. 1. Stoecklin, G. et al. (2002) The EMBO journal 21, 4709-18. PMID: 12198173 2. Ciais, D. et al. (2004) Oncogene 23, 8673-80. PMID: 15467755 3. Schmidlin, M. et al. (2004) The EMBO journal 23, 4760-9. PMID: 15538381 4. Benjamin, D. et al. (2006) Molecular and cellular biology 26, 9497-507. PMID: 17030608 5. Duan, H. et al. (2009) Molecular endocrinology (Baltimore, Md.) 23, 497-509. PMID: 19179481 6. Vignudelli, T. et al. (2010) Molecular biology of the cell 21, 3340-51. PMID: 20702587 7. Viengchareun, S. et al. (2014) Journal of the American Society of Nephrology : JASN 25, 2213-21. PMID: 24700863 8. Zekavati, A. et al. (2014) PloS one 9, e102625. PMID: 25014217 9. Adachi, S. et al. (2014) Nucleic acids research 42, 10037-49. PMID: 25106868 10. Chen, MT. et al. (2015) Scientific reports 5, 16229. PMID: 26542173 | ||||||||
| 注意事項 | For research use only. |
お問い合わせ
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
