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Anti-Human ZMYND8 Polyclonal Antibody (HP036014)

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Vista general
Número de catálogoHP036014
Reactividad de especiesHuman
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human ZMYND8 (His111-Thr388).
Objetivo Protein kinase C-binding protein 1, PRKCBP1, RACK7, ZMYND8, CTCL-associated antigen se14-3, Cutaneous T-cell lymphoma-associated antigen se14-3, Rack7, KIAA1125, Zinc finger MYND domain-containing protein 8
Purificación Purified by antigen affinity column.
Número de acceso Q9ULU4
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

MYND-type zinc finger-containing chromatin reader ZMYND8 is a ~131 kDa protein. Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac. May also act as a transcriptional corepressor for KDM5C and EZH2. Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination. Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters.

1. Adhikary, S. et al. (2016) The Journal of biological chemistry 291, 2664-81. PMID: 26655721
2. Li, N. et al. (2016) Molecular cell 63, 470-84. PMID: 27477906
3. Mukherjee, S. et al. (2020) Journal of biosciences 45. PMID: 31965980
4. Adhikary, S. et al. (2022) Cell death & disease 13, 766. PMID: 36064715
5. Mukherjee, S. et al. (2020) Cell death & disease 11, 1073. PMID: 33323928
6. Gong, F. et al. (2015) Genes & development 29, 197-211. PMID: 25593309
7. Spruijt, CG. et al. (2016) Cell reports 17, 783-798. PMID: 27732854
8. Ghosh, K. et al. (2018) Cell reports 24, 2141-2154.e6. PMID: 30134174
Nota For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
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Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-Human ZMYND8 Polyclonal Antibody

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