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| カタログ番号 | HP036014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ZMYND8 (His111-Thr388). | ||||||||
| ターゲット | Protein kinase C-binding protein 1, PRKCBP1, RACK7, ZMYND8, CTCL-associated antigen se14-3, Cutaneous T-cell lymphoma-associated antigen se14-3, Rack7, KIAA1125, Zinc finger MYND domain-containing protein 8 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9ULU4 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | MYND-type zinc finger-containing chromatin reader ZMYND8 is a ~131 kDa protein. Chromatin reader that recognizes dual histone modifications such as histone H3.1 dimethylated at 'Lys-36' and histone H4 acetylated at 'Lys-16' (H3.1K36me2-H4K16ac) and histone H3 methylated at 'Lys-4' and histone H4 acetylated at 'Lys-14' (H3K4me1-H3K14ac). May act as a transcriptional corepressor for KDM5D by recognizing the dual histone signature H3K4me1-H3K14ac. May also act as a transcriptional corepressor for KDM5C and EZH2. Recognizes acetylated histone H4 and recruits the NuRD chromatin remodeling complex to damaged chromatin for transcriptional repression and double-strand break repair by homologous recombination. Also activates transcription elongation by RNA polymerase II through recruiting the P-TEFb complex to target promoters. 1. Adhikary, S. et al. (2016) The Journal of biological chemistry 291, 2664-81. PMID: 26655721 2. Li, N. et al. (2016) Molecular cell 63, 470-84. PMID: 27477906 3. Mukherjee, S. et al. (2020) Journal of biosciences 45. PMID: 31965980 4. Adhikary, S. et al. (2022) Cell death & disease 13, 766. PMID: 36064715 5. Mukherjee, S. et al. (2020) Cell death & disease 11, 1073. PMID: 33323928 6. Gong, F. et al. (2015) Genes & development 29, 197-211. PMID: 25593309 7. Spruijt, CG. et al. (2016) Cell reports 17, 783-798. PMID: 27732854 8. Ghosh, K. et al. (2018) Cell reports 24, 2141-2154.e6. PMID: 30134174 | ||||||||
| 注意事項 | For research use only. |
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