中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HW561014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human ZNF143 Polyclonal Antibody (HW561014) is a rabbit polyclonal antibody detecting ZNF143 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
|
||||||||
| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ZNF143 (Gly263-Thr438). | ||||||||
| ターゲット | STAF, SPH-binding factor, Selenocysteine tRNA gene transcription-activating factor, Zinc finger protein 143, ZNF143, SBF, hStaf | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P52747 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||||||
| 製品使用情報 |
| ||||||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Zinc finger protein 143 (ZNF143) is a ~68 kDa protein. Transcription factor that activates expression of genes transcribed by both RNA polymerases II and III, and which is required to safeguard mitochondrial activity. Specifically recognizes and binds the Staf-binding site (SBS), a consensus DNA-binding motif present in thousands of promoters. Activates the gene for selenocysteine tRNA (tRNAsec). Activates expression of small nuclear RNA (snRNA) transcribed by RNA polymerases II and III. Also activates expression of mRNAs and acts as a key regulator of cell proliferation and differentiation by specifically activating expression of a subset of nuclear-encoded mitochondrial genes, thereby controlling mitochondrial function. 1. Kubota, H. et al. (2000) The Journal of biological chemistry 275, 28641-8. PMID: 10893243 2. Grossman, CE. et al. (2004) The Journal of biological chemistry 279, 12190-205. PMID: 14702349 3. Yuan, CC. et al. (2007) Molecular and cellular biology 27, 8729-38. PMID: 17938208 4. Vinckevicius, A. et al. (2015) Molecular and cellular biology 35, 4135-46. PMID: 26416877 5. Narducci, DN. et al. (2025) Molecular cell 85, 9-23.e9. PMID: 39708803 6. Myslinski, E. et al. (1998) The Journal of biological chemistry 273, 21998-2006. PMID: 9705341 7. Rincon, JC. et al. (1998) Nucleic acids research 26, 4846-52. PMID: 9776743 8. Myslinski, E. et al. (2006) The Journal of biological chemistry 281, 39953-62. PMID: 17092945 9. Anno, YN. et al. (2011) Nucleic acids research 39, 3116-27. PMID: 21177654 10. Ngondo-Mbongo, RP. et al. (2013) Nucleic acids research 41, 4000-14. PMID: 23408857 | ||||||||
| 注意事項 | For research use only. |
お問い合わせ
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
