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Anti-Human ZRANB3 Polyclonal Antibody (HV828014)

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Vista general
Número de catálogoHV828014
Reactividad de especiesHuman
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human ZRANB3 (Asp27-Arg256).
Objetivo Annealing helicase 2, ZRANB3, Zinc finger Ran-binding domain-containing protein 3, AH2, DNA annealing helicase and endonuclease ZRANB3
Purificación Purified by antigen affinity column.
Número de acceso Q5FWF4
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

DNA annealing helicase and endonuclease ZRANB3 is a ~123 kDa protein. DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks.

1. Yusufzai, T. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 20970-3. PMID: 21078962
2. Ciccia, A. et al. (2012) Molecular cell 47, 396-409. PMID: 22704558
3. Yuan, J. et al. (2012) Molecular cell 47, 410-21. PMID: 22705370
4. Weston, R. et al. (2012) Genes & development 26, 1558-72. PMID: 22759634
5. Badu-Nkansah, A. et al. (2016) The Journal of biological chemistry 291, 8251-7. PMID: 26884333
6. Sebesta, M. et al. (2017) Nature communications 8, 15847. PMID: 28621305
Nota For research use only.
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Datasheet
Download SDS PDF
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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