Anti-IDO1 Polyclonal Antibody (HB992014)

Name: Anti-IDO1 Polyclonal Antibody
Brand: abinScience
SKU: HB992014
Price: 168 USD
Availability: InStock

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100ug

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SDS

Aperçu

Numéro de catalogue

HB992014

Description

Anti-IDO1 Polyclonal Antibody (HB992014) is a rabbit polyclonal antibody detecting IDO1 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human IDO1 (Met1-Gly403).

Cible

INDO, IDO1, Indoleamine-pyrrole 2, 3-dioxygenase, Indoleamine 2, 3-dioxygenase 1, IDO-1, IDO

Purification

Purified by antigen affinity column.

Numéro d'accès

P14902

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Indoleamine 2,3-dioxygenase 1 (IDO1) is a ~45 kDa protein. Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway. Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses. Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells. Acts as a suppressor of anti-tumor immunity. Limits the growth of intracellular pathogens by depriving tryptophan.

1. Metz, R. et al. (2007) Cancer research 67, 7082-7. PMID: 17671174

2. Yuasa, HJ. et al. (2007) Journal of molecular evolution 65, 705-14. PMID: 18026683

3. van Baren, N. et al. (2015) Frontiers in immunology 6, 34. PMID: 25691885

4. Uyttenhove, C. et al. (2003) Nature medicine 9, 1269-74. PMID: 14502282

5. Munn, DH. et al. (2013) Trends in immunology 34, 137-43. PMID: 23103127

6. Schmidt, SV. et al. (2014) Frontiers in immunology 5, 384. PMID: 25157255

Note

For research use only.

Images

Reférences

Fiche technique

Anti-IDO1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

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