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| カタログ番号 | HB992014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-IDO1 Polyclonal Antibody (HB992014) is a rabbit polyclonal antibody detecting IDO1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human IDO1 (Met1-Gly403). | ||||||||
| ターゲット | INDO, IDO1, Indoleamine-pyrrole 2, 3-dioxygenase, Indoleamine 2, 3-dioxygenase 1, IDO-1, IDO | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P14902 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Indoleamine 2,3-dioxygenase 1 (IDO1) is a ~45 kDa protein. Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway. Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses. Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells. Acts as a suppressor of anti-tumor immunity. Limits the growth of intracellular pathogens by depriving tryptophan. 1. Metz, R. et al. (2007) Cancer research 67, 7082-7. PMID: 17671174 2. Yuasa, HJ. et al. (2007) Journal of molecular evolution 65, 705-14. PMID: 18026683 3. van Baren, N. et al. (2015) Frontiers in immunology 6, 34. PMID: 25691885 4. Uyttenhove, C. et al. (2003) Nature medicine 9, 1269-74. PMID: 14502282 5. Munn, DH. et al. (2013) Trends in immunology 34, 137-43. PMID: 23103127 6. Schmidt, SV. et al. (2014) Frontiers in immunology 5, 384. PMID: 25157255 | ||||||||
| 注意事項 | For research use only. |
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