Anti-IDO1 Polyclonal Antibody (HB992014)

Name: Anti-IDO1 Polyclonal Antibody
Brand: abinScience
SKU: HB992014
Price: 168 USD
Availability: InStock

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Обзор

Каталожный номер

HB992014

Описание

Anti-IDO1 Polyclonal Antibody (HB992014) is a rabbit polyclonal antibody detecting IDO1 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Реактивность видов

Human

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human IDO1 (Met1-Gly403).

Цель

INDO, IDO1, Indoleamine-pyrrole 2, 3-dioxygenase, Indoleamine 2, 3-dioxygenase 1, IDO-1, IDO

Очистка

Purified by antigen affinity column.

Номер доступа

P14902

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Indoleamine 2,3-dioxygenase 1 (IDO1) is a ~45 kDa protein. Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway. Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses. Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells. Acts as a suppressor of anti-tumor immunity. Limits the growth of intracellular pathogens by depriving tryptophan.

1. Metz, R. et al. (2007) Cancer research 67, 7082-7. PMID: 17671174

2. Yuasa, HJ. et al. (2007) Journal of molecular evolution 65, 705-14. PMID: 18026683

3. van Baren, N. et al. (2015) Frontiers in immunology 6, 34. PMID: 25691885

4. Uyttenhove, C. et al. (2003) Nature medicine 9, 1269-74. PMID: 14502282

5. Munn, DH. et al. (2013) Trends in immunology 34, 137-43. PMID: 23103127

6. Schmidt, SV. et al. (2014) Frontiers in immunology 5, 384. PMID: 25157255

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-IDO1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

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