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| カタログ番号 | HY158014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-IFI30 Polyclonal Antibody (HY158014) is a rabbit polyclonal antibody detecting IFI30 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human IFI30 (Met1-Lys250). | ||||||||
| ターゲット | IP30, GILT, Gamma-interferon-inducible protein IP-30, IFI30, Legumaturain, Gamma-interferon-inducible lysosomal thiol reductase | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P13284 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Gamma-interferon-inducible lysosomal thiol reductase (IFI30) is a ~27 kDa protein. Lysosomal thiol reductase that catalyzes protein disulfide bonds reduction. Plays an important role in antigen processing and presentation, of namely both major histocompatibility complex (MHC) class I- and class II-restricted antigen by reducing the disulfide bonds of endocytosed proteins and facilitating their unfolding and optimal degradation. Shares with thioredoxin a reduction mechanism in which the N-terminal cysteine thiol group in the CXXC active site motif initiates a nucleophilic attack on the substrate disulfide bond,resulting in the formation of a mixed disulfide-linked enzyme-substrate intermediate (Probable). Subsequent intramolecular attack by the second cysteine thiol group enables the release of the reduced substrate and oxidized enzyme (Probable). Lysosomal cysteine is a physiological reducing agent that is capable of reducing IFI30, so that it can catalyzes the next reaction. 1. Arunachalam, B. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 745-50. PMID: 10639150 2. Phan, UT. et al. (2000) The Journal of biological chemistry 275, 25907-14. PMID: 10852914 | ||||||||
| 注意事項 | For research use only. |
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